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Introduction: Direct vs Indirect IGF-1 Pathway Activation Two fundamentally distinct approaches to IGF-1 pathway research have emerged: direct exogenous IGF-1 administration (IGF-1 LR3) and indirect stimulation through growth hormone (HGH), which promotes hepatic IGF-1 synthesis

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In conclusion, most of the studies referenced above provided adequate information to formulate summaries, although some text descriptions were rather vague in the methodology used