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NICE TA875 specifies that treatment should be reviewed at two years, with continuation only where clinically appropriate within the terms of the appraisal

Meanwhile, Zealand Pharma is advancing petrelintide, a long-acting analog that in a Phase Ib study showed a promising efficacy and safety profile

Receptor Profile : Cagrilintide acts as a nonselective agonist at amylin receptors (AMY1/2/3) and the calcitonin receptor, which are involved in appetite regulation, gastric emptying, and energy homeostasis

Improved blood sugar control and weight loss in T2D: A 32-week phase 2 trial, involving 92 participants with T2D, revealed that weekly doses of 2.4 mg cagrilintide + semaglutide reduced HbA1c levels by -2.2%, fasting blood sugar by -3.3 mmol/L, and body weight by -15.6% from baseline [12]