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Inhibiting NNMT with 5-Amino-1MQ restores NAD+ pools, which activates AMPK (AMP-activated protein kinase), the cellular energy sensor that shifts metabolism from glucose storage to fat oxidation

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While there is significant debate on whether this sustained immune response is the primary mechanism responsible for long-COVID or a byproduct of other underlying mechanisms (Altmann et al., 2023), a common theme among these disorders appears to be sustained inflammatory cascades that persist beyond the resolution of the initial insult (Clark, 2022)