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AMP research exploits their: Broad-spectrum bactericidal activity via membrane perturbation (colloido-osmotic mechanism, pore formation) Low resistance to bacterial selection (physical mechanism, little subject to mutation) Potential as antibiotic substitute in multi-resistance context Immunomodulatory activity : LL-37 stimulates leukocyte migration, neovascularisation, reepithelialisation In preclinical research, new-generation synthetic antimicrobial peptides (derivatives of magainin, indolicidin, protegrins) are tested on infected wound models

Schmitt-Ulms G, Legname G, Baldwin MA, Ball HL, Bradon N, Bosque PJ, Crossin KL, Edelman GM, DeArmond SJ, Cohen FE, Prusiner SB (2001) Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein

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