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While exercise has far more effects than any single pathway modulator, ERR activation does appear to replicate aspects of exercise training at the molecular and metabolic level

Potential concerns include: Unknown product quality Contamination or sterility issues Incorrect dosing Injection site reactions Allergic or immune reactions Medication interactions Hormonal or metabolic effects Unclear long-term safety Lack of monitoring Delayed treatment for an actual injury or medical condition Medical oversight is especially important for patients with autoimmune conditions, cancer history, active infections, chronic inflammatory disorders, cardiovascular concerns, hormone-sensitive conditions, or complex medication regimens

If the pain persists and is generally not relieved with time or cortisone injections, then a patient may consider surgery since its likely there are more problems in the shoulder

Atmos Environ 164:416430