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Luteolin suppresses this pathway by preventing phosphorylation and degradation of the inhibitory protein IB, thereby blocking nuclear translocation of NF-B p65 and reducing transcription of pro-inflammatory cytokines (TNF-, IL-1, IL-6), iNOS, COX-2, and adhesion molecules ( Chemokines such as CCL2 and CCL5 play essential roles in immune cell recruitment and polarization within reproductive tissues, and their dysregulation promotes chronic inflammation, macrophage infiltration, angiogenesis, and fibrotic remodeling characteristic of endometriosis and related disorders (Li et al., 2022

L-Carnitine deficiency may result in elevated levels of triglycerides in the blood that can contribute to overall metabolic imbalances

Once the double bond is on the fourth carbon of the acyl-CoA at the beginning of a -oxidation cycle it begins to be oxidized

Tsimikas S , Gordts PLSM , Nora C , Yeang C , Witztum JL