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The developmental stages S1, S2, S3, S4, S5, and S6 represents 60, 67, 74, 78, 82, and 86 days after full-bloom (DAFB), respectively

Notably, disturbances in lipid metabolism appear to be a common denominator across multiple studies

Specifically, IGF1 exerts a significant protective effect on four dimensions of sleep disturbance: sleep quality, sleep efficiency, sleep disturbance and daytime dysfunction (sleep quality: OR = 0.389, p = 0.010

Finally, we have shown that a TCR with too low affinity to function in effector T cells was able to confer potent, antigen-specific suppression when expressed in a T reg cell 114 , which suggests that the signal strength required to activate a T reg cell is less than that required to activate effector T cells