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As (III) exerts dual-barrier disruption through CAPN-1 activation: rapid calcium influx triggers VE-cadherin degradation at adherens junctions, while chronic exposure downregulates ACE2/MasR axis, impairing the protective renin-angiotensin system (117, 118)

o., 21 days) ( Naringin is a flavanone glycoside with antioxidant, anti-inflammatory and anti-apoptotic efficacy, mainly found in citrus fruits, especially in the peels of tangerines, sweet oranges and lemons

doi: 10.1016/j.enceco.2024.07.002 59 DingJ.LiuY.GaoY.ZhangC.WangY.XuB.et al

Third, the single-center cohort limits generalizability, and selection bias may exist due to the exclusion of patients lost to follow-up