bso glutathione depletion Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via Role of Depletion of cellular GSH by

A study in dermal fibroblasts found that hypoxia promotes collagen deposition via HIF-1 and TGF/Smad signaling and that HIF-1 knockdown inhibits TGF-/Smad signaling (Mingyuan et al ., 2018)

Originally characterized at the University of Florida by the Stephen ORahilly and Robert Kraft groups, the compound has been studied in preclinical research for body composition, adipose tissue lipolysis, glucose homeostasis, skeletal muscle aging, and metabolic disease endpoints

Medications that regulate fatty acid oxidation can effectively minimize their accumulation in pancreatic tissue, thereby alleviating the oxidative stress and inflammation associated with fatty acids

Furthermore, inhibition of glutamine metabolism or cysteine deficiency increases ROS production and lipid peroxidation, thereby further facilitating ferroptosis (Galluzzi et al., 2015)