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Moreover, GPX4 levels were elevated on treatment with SCLA2 and derived alkyne probes SCLA2a and SCLA2b (Extended Data Fig

Intracellular iron overload serves as a key factor in ferroptosis ( 4.1.1 Modulation of ferritin, ferroportin, and hepcidin: the pathways governed by HO-1 Iron metabolism-related proteins play a critical role in the process of iron metabolism

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It is thought to produce an analgesic effect by reducing levels of pain mediators such as tumor necrosis factor-alpha, prostaglandins, interleukin 1-beta, and beta-endorphins, as well as by increasing local microcirculation