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In support of these data, in a prospective elderly cohort in Singapore ( n 470, mean age 73), lower baseline ergothioneine levels were associated with poorer baseline cognitive performance and faster rates of decline in function in multiple cognitive domains over 5 years of follow-up (Reference Wu, Kan and Cheah78)

A cofactor in the methionine production is tetrahydrofolate (THF) that transfers a methyl group to the -SH group of homocysteine, the precursor of methionine

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a transcription factor) is at least partially responsible for the decrease in erythropoietin production 15,16 and that this downregulation is reversible (see below)