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doi: 10.1152/ajpendo.00462.2004 [DOI] [PubMed] [Google Scholar] 110

demonstrated the deletion of exon 2 (thus Class 2 mRNAs) in mice did not affect viability, growth, and maintenance of circulating IGF-1 levels [94], and the exact physiological roles of Class 1 and Class 2 proteins remain to be determined