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Additionally, proteins such as acetyl CoA carboxylase (ACC), acyl-CoA synthetase long-chain family member 4 (ACSL4), lysophosphatidylcholine acyltransferase 3 (LPCAT3), and lipoxygenases (LOX) influence PUFA metabolism and oxidation, while glutathione peroxidase 4 (GPX4) fulfills a crucial role in the antioxidant system by directly converting lipid hydroperoxides to lipid alcohols [16, 17]

Artesunate induces apoptosis, autophagy, and ferroptosis in diffuse large B-cell lymphoma (DLBCL) cells by impairing STAT3 signaling

Flavonoids such as chamanetin have been shown to bind to mutant ataxin-3 ( 7.2 kcal/mol) and exhibit favorable pharmacokinetics 16

It has been found that mutations in the amyloid protein precursor ( APP ), presenilin-1 ( PSEN1 ), and presenilin-2 ( PSEN2 ) genes are associated with autosomal dominant early-onset familial AD, while apolipoprotein E4 ( APOE4 ) represents the most significant genetic risk factor for late-onset sporadic AD, contributing to the deposition of A peptides and hyperphosphorylated tau proteins (Giau et al., 2019