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Yet, potentially more realistic than laboratory simulations of environmental conditions mimicking the distant future are experiments designed around short-term environmental changes that resemble far less predictable and even chaotic weather events (Saunders et al., 2002

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In a series of 181 patients with lumbar disc herniations in 65% of the cases the site of failure was the annulus endplate junction with bony changes or avulsions at the posterior rims of the endplates