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The FDA defines a prognostic biomarker as a measured characteristic that reflects a patients degree of risk of disease occurrence or progression that is independent of treatment while a predictive biomarker categorizes patients by their likelihood to respond favorably or adversely to a particular treatment

erinaceus polysaccharide inhibited the progression of type 2 diabetes by inducing an imbalance in glucose metabolism, activating the adenosine monophosphate (AMP)-activated protein kinase (AMPK)/SREBP-1c signaling pathway, and increasing beneficial metabolites in the liver through the intestinalhepatic axis

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Angiogenesis in the lungs can be stimulated by factors such as hypoxia, extensive lung tissue injury, and oncogene and cytokine activation (Siafakas et al., 2007)