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6.2 Glaucoma Glaucoma is responsible for roughly 12% of global blindness, making it a substantial cause of permanent vision loss (Tham et al., 2014)

N-acetylglutamate synthase deficiency: an insight into the genetics, epidemiology, pathophysiology, and treatment

10.1038/emboj.2010.297 75

Decreased glomerular filtration, as well as the effects on tubular handling of uric acid of hydration, certain organic acids, drugs (in particular thiazide and loop diuretics) and exogenous toxins (e.g., lead), all impair renal excretion of uric acid ( Table 1 - 3 )