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As expected, the bacterial cellulose- g -poly(acrylic acid) [BC-g-P(AA)] hydrogel was pH-responsive, as the amount of insulin released in the first 2 h of incubation in the simulated gastric fluid was 90% [59]

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Thus, determining whether metabolic changes observed in vivo are the either the cause or the result of a toxicity event, represents a significant challenge in metabolomics ( On the other hand, in vitro metabolomics can overcome the limitations of in vivo studies and reveal early events following drug exposure

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