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(PubMed) Wong CY, Qiuwaxi J, Chen H, et al

A systematic review of the relevant literature, summarized herein, indicates that this chronotherapeutic hypothesis is unaddressed within the clinical literature on antioxidant therapy for brain disorders such as schizophrenia

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells that serves as a critical electron carrier in the mitochondrial electron transport chain and as a substrate for sirtuins (SIRT1-7), PARPs, and CD38

For example, O 2 triggers the intracellular p38 MAPK and JNK pathways, promoting apoptosis while also generating other ROS (such as H 2 O 2 ) to further amplify oxidative damage [218]