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Disclosures: David Lee: Nothing to Disclose, Caroline Klindt-Morgan: Nothing to Disclose, Dominick Hellen: Nothing to Disclose, Ashley Bennett: Nothing to Disclose, Paul Dawson: Nothing to Disclose, Saul Karpen: Albireo/Ipsen: Consultant, Mirum: Consultant, HemoShear: Consultant, Intercept: Consultant 718 THE USC PSYCHOSOCIAL CHECKLIST: A TOOL TO REMOTELY SCREEN POTENTIAL LIVER TRANSPLANT (LT) CANDIDATES WITH ALCOHOL-ASSOCIATED LIVER DISEASE (ALD) PRIOR TO HOSPITAL TRANSFER Brooke Edwards 1 Samantha Ramirez 1 John Pappas 2 Jennifer Dodge 2 Hyosun Han 3 Jeffrey Kahn 2 Norah Terrault 3 Aaron Ahearn 2 Brian Lee 4 , 1 Keck Medical Center of USC, 2 Keck USC, 3 University of Southern California, 4 Keck School of Medicine Background: ALD is the #1 indication for LT, leading to a rise in inter-hospital transfer requests for LT evaluation

When patients express interest in combining these substances, clinicians should conduct a thorough assessment including medical history, current medications, baseline kidney function, and treatment goals

doi: 10.1093/ibd/izae069 199 ShimoyamaTYamamotoTYoshiyamaSNishikawaRUmegaeS

This FGF8 signaling cascade subsequently activates Wnt1 expression in the midbrain, which in turn upregulates the Engrailed-1/2 transcription factorsfirst detected at embryonic days 11.514 in micewhereupon their sustained expression becomes essential for the maintenance and survival of VTA DA neurons (Hegarty et al., 2013)