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Parameters to monitor Weight Serum electrolytes BUN and creatinine Uric acid Hearing (in high doses) Potassium-sparing diuretics See Table 12-7 for a list of potassium-sparing diuretics, their usual dosage range, and adverse effects associated with these medications

Vitamin B12 deficiency has been linked to decreased bone density and increased risk of osteoporosis

Individuals receiving therapeutic B12 injections constitute the primary at-risk group

In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)