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In AIH, it has been proved that a signaling pathway mediated by hydrocarbon receptor (AhR) was necessary for ongoing AIH-like pathology, and Lactobacillus reuteri could release an AhR ligand, indole-3-aldehyde (I3A), thus promoting the differentiation of CD8 T cells in vitro and AIH-like pathology in mice [69]

Despite the enhanced GPx activity, GSSG concentration of pathogen-inoculated susceptible genotypes at 7 DPI remained significantly lower mainly due to enhanced GR activity, which rapidly converts GSSG in to GSH