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GO Term/KEGG analysis Quantitative analysis of proteomics and transcriptomics data was performed using WormEnrichr ( Specific methods for data cut-offs and sorting are detailed in the figure legends or text corresponding to each analysis

FGF-21 is a powerful regulator of glucose and lipid metabolism, which is significantly increased under certain conditions, such as mitochondrial dysfunction (see (185) for a review)

TNF-, belonging to the Fas family, exhibits a robust interaction with the Fas ligand and triggers caspases, initiating programmed cell death ( Moreover, endothelial and leukocyte cell adhesion molecules like ICAM-1 and VCAM-1 promote the recruitment of leukocytes and immune cells to the site of injury through their interactions with endothelial cells (Frugier et al., 2010)

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