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The significance of bacterial GSH has been demonstrated using different GSH-deficient Rhizobium mutants (Muglia et al., 2008

Available additional data will be presented at the conference

Our results revealed that betaine and DMG levels, as well as the betaine: choline ratio, were reduced in COC users, whereas choline, serine, and the DMG: betaine ratio were significantly increased in COC users compared with controls (Table 4)

Importantly, gastrointestinal adverse events (nausea, vomiting, diarrhoea) occurred in 3045% of participants during dose escalation but typically resolved within 48 weeks