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3.2 Growth results in the tested matrices Table 2 and Figure 3 collectively illustrate the growth dynamics of the L

It has been demonstrated in mice with adipocytes deficient in mitochondrial transcription factor A that isolated mitochondrial dysfunction in adipose tissue can cause lipodystrophy and lead to MS and chronic inflammation (Vernochet et al., 2014)

Both of these processes are mainly regulated by the signaling pathway: insulin-like growth factor-1 (IGF-1) phosphoinositide-3-kinase (PI3K) protein kinase B (Akt) mammalian target of rapamycin (mTOR)