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2019 (Lancet HIV, n=61) Phase II investigator-initiated trial in HIV-NAFLD: about 32% liver-fat reduction and lower fibrosis-progression rate versus placebo at 12 months

Reviewer: Halima T

The delayed onset of RTT symptoms is believed to be associated with the postnatal accumulation of methylated CpA dinucleotides (mCpA) and MECP2 binding to these sites, contributing to progressive neurodevelopmental abnormalities (110)