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In contrast, NADPH oxidase and p53 (especially acetylation-defective mutant p53) act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively

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This geological event raised a vast body of water over 650 hectares to an altitude of about 145 meters above sea level in the limestone mountain area, forming the three interconnected branches of the lake: P Lm, P L, and P Lng