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Oral Cancer Treatment Treatment depends on: Whether cancer cells have spread to other parts of your body Size and location of the main tumor Your overall body health Type of oral cancer Your age Treatment options include: Radiation therapy and chemotherapy Drugs to destroy any remaining cancer cells Drugs like ibuprofen or acetaminophen and stronger ones like morphine for pain relief Nutritious food that is gentle and smooth to the throat because poor appetite and weight loss are common Mouth hygiene is crucial