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Discussion In the present echocardiography sub-study of the MIRAD trial, no improvement was observed in either systolic, diastolic left ventricular function or LVMi following treatment with high-dose eplerenone for a duration of 26 weeks in a cohort of high-risk type 2 diabetes patients without known heart failure

The IGF-IR interaction results in phosphorylation and adsorption of insulin receptor 1 (IRS1) or insulin receptor 2 (IRS2) by activating PI3K and then Akt [14]