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It is found that shikonin can stimulate RIPK1 and RIPK3-dependent necrosis and directly promote the up-regulation of DAMPs through autophagy, in which ROS accumulation and NF-B pathway activation may be the main mechanisms of cell necrotizing apoptosis (121)

Effects of organoselenium compound 2-(5-selenocyanatopentyl)- benzo[de]isoquinoline 13-dione on cisplatin induced nephrotoxicity and genotoxicity: an investigation of the influence of the compound on oxidative stress and antioxidant enzyme system