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EV2G), a ferroptosis inducer that inhibits the cystine/glutamate antiporter (system XC ) known to provide cystine (i.e., the oxidized form of cysteine) required for glutathione synthesis (Dixon et al, 2012)

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Therefore, S -glutathionylation of GAPDH, aldolase and TPI can be a key element in GR-mediated glutathione homeostasis during oxidative stress (Figure 5)