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The Numbers Are Sobering: Patients with HH face a 20-fold increased risk of liver cancer, with an absolute risk of 6% among men and 1.5% among women at 10 years of follow-up A comparative study found that patients with HH had a relative risk of 1.8 for developing hepatocellular carcinoma and 1.8 for non-hepatic cancers compared to matched controls with non-iron-related chronic liver disease The incidence of hepatocellular carcinoma in individuals with hereditary hemochromatosis is 200 times greater than in the general population But the cancer risk extends beyond the liver

As expected, the WT system interacted with the membrane through the extended loop, involving the amino-acid residues F27 and F28, which were inserted into the palmitoyl oleoyl phosphatidylcholine (POPC) membrane (Fig