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10.3390/cancers13092256 Cancers (Basel)

These signalling pathway intermediates are found in diverse cellular regulatory signalling axis, including cell proliferation, survival, cell cycle, cytoskeletal functions, and transcription

The first of these, GCLC-a (Figure 2B), would cleave after position 217, and is an exact match to P4-P1 of nsp5/6, but with an A in P1, a highly favorable residue for that position, although SCoV has a G there, and SCoV2 has an S