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Transport of 14c-gamma-aminobutyric acid into brain, cerebrospinal fluid and choroid plexus in neonatal and adult rats

Front Pharmacol 14:1147414

The genetic inactivation of the regulatory component in the rate-limiting step of GSH biosynthesis ( GCLM ) or the treatment with L-BSO further depleted endogenous GSH in both ADH5 and WT cells, denoting that the mechanism by which ADH5 contributes to GSH homeostasis is downstream GSH synthesis