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CB1-Rs and CB2-Rs can also activate other intracellular signaling cascades, including the mitogen-activated protein kinase (MAPK) cascade, the phosphatidylinositol 3-kinase (PI3K) cascade, and nitric oxide production [45]

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Carnosine also exhibits the ability to provide skin photo-protection against a broad range of solar-simulated radiation (SSR, 300750 nm) 23

However, allicin is unstable and quickly decomposes to polysulfanes, ajoene, and other sulfur compounds during heating ( Author Disclaimer Crushed garlic acts as strong irritant and activates the transient receptor potential channel (TRPA1) in pain-sensing neurons, resulting in pain, inflammation and neurotoxic effects ( Publishers Note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers