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Previous studies also showed that some patients showing no evident cerebellar atrophy respond well to immunotherapies and that the clinical improvement correlates well with a fall in Ab titers [3, 6]

Regarding stability and biocompatibility, novel smart coatings or hybrid structures can be developed: for example, designing pH- or enzyme-responsive polymer shells that remain stable in circulation but degrade at the tumor site to expose targeting ligands, enabling precise delivery