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Interestingly, bioinformatic analyses conducted on bulk tissue data obtained from healthy human brain tissue donors revealed that endothelial cells and microglia were the predominant senescent cell types, driven by CDKN1A/ p21 WAF1 /CIP1 (42) revealing potential differences in senescent cell types between healthy and diseased states

Lab research shows mTOR + ULK1 inhibitor combo induces A549 cell apoptosis (154, 155)

The cleavage of GST from the target protein can be challenging, especially if the cleavage site is not efficiently recognized by the protease or if the GST tag affects the accessibility of the cleavage site

Integrating these systems with zebrafish xenografts could map spatial-temporal interactions between malignant cells and specific TME components