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Organization of Chromatin by Intrinsic and Regulated Phase Separation

Chen et al (140) demonstrated that epigenetically upregulated NOP2/Sun RNA methyltransferase family member 2 (NSUN2) binds to the mRNA of SLC7A11, catalyzes 5-methylcytosine methylation and then recruits the specific recognition protein Y-box-binding protein 1 to form a stable protein-RNA complex, thereby enhancing the stability of SLC7A11 mRNA and promoting the upregulation of SLC7A11 expression at both the mRNA and protein levels

A small clinical study in healthy volunteers shows that pretreatment with quercetin increases plasma levels and prolongs the half-life of a single dose of cyclosporine (Neoral, Sandimmune), a substrate of CYP3A4