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Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism Archives of Toxicology Springer Nature Link 5 things to know about acetaminophen CNN Jenny McCarthy's Glutathione and Tylenol Claims: Medical Toxicologist Weighs In MedPage Today Tylenol and Fatty Liver: What You Need to Know

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doi: 10.1002/0471140856.tx2011s67

Nutrients, 11, 2073

53 , 54 Notably, most of the older tyrosinase inhibitors were previously tested using an in vitro mushroom tyrosinase model, but showed only limited efficacy in inhibiting the human tyrosinase, while thiamidol 0.2% was identified as being the most effective inhibitor of the human tyrosinase, corresponding to its good clinical efficacy 6871 (Figure 2)