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This could be validated by several recent studies which implicate that pericyte dysfunction is an early sign for cognitive decline [55, 56]

Although NF-B is under the control of extracellular stimuli, it is inhibited by an inhibitor of B (IB) which sequester NF-B in the cytosol and prevent its localization (Al-Kuraishy et al

The salutary effects of GLP-1RA on endothelial function could also be exploited for ED amelioration 96 , as the GLP-1 receptor was detected in endothelial cells and GLP-1RA were found to affect endothelial function by stimulating nitric oxide production 99