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Estimation of Cumulative AUC and Target Attainment For comparing the target attainment between cohorts, the individual cumulative AUC (cAUC) for each patient was derived from the integration of the concentration over time, using the empirical Bayes estimates of individual CL over the entire treatment course as follows: Target attainment was defined as the achieved cAUC divided by the target cAUC for the patient, multiplied by 100%

Interestingly, similar effects are observed when measuring total lipid peroxidation using C11-BODIPY581/591 (Figure 2E)

doi: 10.1056/NEJM199704033361404

Metabolic engineering of cofactor F420 production in Mycobacterium smegmatis