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Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-kappaB activation

Here we present the cryo-electron microscopy structure of Cdiff RNA polymerase in complex with fidaxomicin and identify a crucial fidaxomicin-binding determinant of Cdiff RNA polymerase that is absent in most gut microbiota such as Proteobacteria and Bacteroidetes

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doi: 10.1097/MIB.0b013e318292477c 223 Prez-BrocalVGarca-LpezRVzquez-CastellanosJFNosPBeltrnBLatorreAet al