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ARR2 facilitates the interaction between SORLA and the ESCRT-0 complex to promote lysosomal localization and degradation of SORLA To elucidate the molecular mechanism by which ARR2 enhances the lysosome localization of SORLA, we examined whether ARR2 could facilitate the complex assembly between SORLA and the ESCRT-0 complex, which acts as the initial step in the lysosomal sorting pathway [49, 50]

Proc Am Assoc Cancer Res 44:1485, 2003

Their formulations tend to have few ingredients, and they avoid potential irritants like fragrances, making them an excellent choice for individuals with sensitive skin

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