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Targeting the ferroptosis pathway offers a promising therapeutic strategy, particularly for tumors resistant to conventional treatments

The review confirmed that animal and human studies demonstrate adequate protein nutrition is crucial for maintenance of GSH homeostasis, and that enteral or parenteral cystine, methionine, N-acetyl-cysteine, and L-2-oxothiazolidine-4-carboxylate are effective cysteine precursors for tissue GSH synthesis

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Figure 9: Chronic liver disease (steatosis, steatohepatitis, and cirrhosis, respectively, based on severity of progression) is associated with decreased harvesting of energy and increased production of reactive oxygen species (ROS)