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however, in reducing iron deposition, baicalein is superior to deferrioxamine and its mechanism may be related to the up regulation of hepcidin and its regulators bone morphogenetic protein 6 (BMP-6), SMAD family member 4 (SMAD4), and transferrin receptor 2 (TfR2) at the protein and mRNA levels ( Baicalin Baicalin is the 7-hydroxyl group of baicalein, followed by glucuronide

For example, in lipopolysaccharide (LPS)-induced acute kidney injury, downregulation of HMGB1 and NCOA4 expression inhibits ferritinophagy, thereby alleviating ferroptosis in renal tubular cells (Tang et al., 2021)

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Osgstu3 and osgtu4, encoding tau class glutathione S-transferases, are heavy metal- and hypoxic stress-induced and differentially salt stress-responsive in rice roots 1