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Both 5AC and decitabine undergo phosphorylation prior to incorporation into DNA but 5AC additionally incorporates into RNA, which generates the main difference between the two drugs

Heaney ML, Gardner JR, Karasavvas N, Golde DW, Scheinberg DA, Smith EA, et al

Strategies focused on these AAs, either alone or in combination with enzyme- or microbiota-targeted interventions, may provide significant advances in the personalized management of CD as a complex immune-mediated disorder