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A study of the neuroprotective capacity of VEGF in an experimental model of PD showed that rats receiving continuous local infusion of VEGF into the striatum via encapsulated hamster kidney VEGF (hVEGF)-secreting cells showed a reduction in amphetamine-induced rotational behavior and neuronal protection (Hsieh et al

Mar2013;35(1):21-8

Together, these results suggest that salivary tissue degeneration in human radiotherapy patients is due to loss of progenitors and cholinergic signaling