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Glial modulation of synapse development and plasticity: oligodendrocyte precursor cells as a new player in the synaptic quintet

For example, binding of SCFAs to FFAR2 and GPR109A in intestinal epithelial cells stimulates K+ efflux and hyperpolarization, leading to activation of the inflammatory vesicle-activating protein NLRP3, which, in turn, induces the release of IL-18, contributing to the maintenance of integrity, repair, and intestinal homeostasis (190)