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For instance, hyperuricemia can be induced in juvenile zebrafish by using PO or sodium xanthine, but these models still require further validation as GA models ( Table 1 )

Evaluation of Clinical Efficacy of a Venotonic Drug: Lessons of a Therapeutical Trial with Hemisynthesis Diosmin in Heavy Legs Syndrome. Journal de Maladies Vasculaires, 1998

In controlled laboratory conditions, it has been shown to modulate inflammatory responses by reducing excessive signaling associated with chronic inflammation models