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Finally, more stable water isotope records from Antarctic ice and firn core data are more than needed to evaluate models and to lead modeldata investigations of past climates, comparing SAT 18 O relationships from different water-stable-isotope-enabled models, in line with the work of the Stable Water Isotope Intercomparison Group 2 (SWING) (IPCC, 2022)

k cat and K m values could not be obtained due to the low activity of the mutant enzymes

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The disulfide rebridging capacity of these reagents was optimised on the clinically relevant IgG1 trastuzumab, resulting in a general method which allows for the generation of site-selectively modified native trastuzumab with over 90% homogeneity (no disulfide scrambling) without the need for protein engineering or enzymatic conjugation