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Similarly, Natural compounds such as oleanolic acid (OA) and ursolic acid (UA) can inhibit the growth of BPH cells by inducing autophagy and reducing the expression of the IL-8 axis [107]

For patients requiring chronic NSAID therapy who are at high risk for peptic ulcer disease, co-administration of proton pump inhibitors provides effective prophylaxis by directly suppressing gastric acid secretion

To date, 36 SAEs have been reported including psychiatric hospitalizations (12), variceal bleeding or ascites (6), systemic infections (5), major adverse cardiovascular events (4), trauma or overdoses (3), pneumonia/chronic obstructive pulmonary disease (2), treatment of HCC (2), abnormal labs or acute kidney injury (2)